http://www.rssboard.org/rss-specification 720 http://xtf.cdlib.org:8080/xtf/search?docsPerPage%3D100;smode%3Dsimple;subject%3Dalcohol;subject-join%3Dexact Results for your query: docsPerPage=100;smode=simple;subject=alcohol;subject-join=exact Mon, 01 Jan 2007 12:00:00 GMT http://xtf.cdlib.org:8080/xtf/data/text/1683/1683.txt We review evidence for and against the ‘red wine hypothesis’, whereby red wine is more likely to confer cardiovascular benefits than white. As background, there is a strong epidemiological and mechanistic evidence for J-shaped relation between alcohol intake and total mortality. However, epi- Resveratrol; Molecular mechanisms; Sirtuin demiological data favouring a specific benefit of red over white wine are not strong and the ‘French paradox’ could at least in part be explained by confounding factors. More convincing evidence is that human studies with de-alcoholized red but not white wine show short-term cardiovascular benefits. The specific components of the de-alcoholized wine that are active on cardiovascular endpoints, are the polyphenols found in red wine, especially resveratrol. The effects of resveratrol on isolated tissues or organs are well-described including molecular mechanisms leading to decreased arterial damage, decreased activity of angiotensin-II, increased nitr... http://xtf.cdlib.org:8080/xtf/data/text/1683/1683.txt Mon, 01 Jan 2007 12:00:00 GMT