http://www.rssboard.org/rss-specification 720 http://xtf.cdlib.org:8080/xtf/search?docsPerPage%3D100;f4-subject%3DBiological%20Sciences%3A%20Genetics Results for your query: docsPerPage=100;f4-subject=Biological Sciences: Genetics Tue, 21 Aug 2001 12:00:00 GMT http://xtf.cdlib.org:8080/xtf/view?docId=nlm/pnas/pnas.xml We explore the impact of a host genetic factor on heterosexual HIV epidemics by using a deterministic mathematical model. A protective allele unequally distributed across populations is exemplified in our models by the 32-bp deletion in the host-cell chemokine receptor CCR5, CCR5Δ32. Individuals homozygous for CCR5Δ32 are protected against HIV infection whereas those heterozygous for CCR5Δ32 have lower pre-AIDS viral loads and delayed progression to AIDS. CCR5Δ32 may limit HIV spread by decreasing the probability of both risk of infection and infectiousness. In this work, we characterize epidemic HIV within three dynamic subpopulations: CCR5/CCR5 (homozygous, wild type), CCR5/CCR5Δ32 (heterozygous), and CCR5Δ32/CCR5Δ32 (homozygous, mutant). Our results indicate that prevalence of HIV/AIDS is greater in populations lacking the CCR5Δ32 alleles (homozygous wild types only) as compared with populations that include people heterozygous or h... http://xtf.cdlib.org:8080/xtf/view?docId=nlm/pnas/pnas.xml Sat, 01 Aug 1970 12:00:00 GMT